I believe DCM uses that program to make a lot of his work these days, you could try asking him directly.

Comics are not that hard to make. They just take a lot of time. Photoshop and illustrator would work fine for what you are likely to do. Gimp if you can't afford photoshop will work as well. Scrap paper and a ball point pen plus some scissors and tape for the thumbnail layouts. Doodle away on a panel idea until you find what you want to use, cut and past it to a clean sheet. Do this until you have a full page, and then proceed to finished art using the ball pen roughs as your guide. The only things a web cartoonist is likely to run short on is time, energy and ambition. In that department I'm afraid i can not help you.

Good luck with your comic, and be sure to post it here so we all can see the results.

Me too. Sometimes it's best to jump in and see what you can do right now. You can read an art book later if you need to.